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What is prednisone?

Prednisone is a synthetic hormone, commonly called a steroid, specifically a glucocorticoid type of steroid. Prednisone is very similar to the hormone cortisone, which is naturally produced by your own body. Prednisone is used to treat many medical conditions. There are several types of steroids, each with a different effect. Glucocorticoid steroids are very different from androgenic steroids, which have become known as “performance enhancing” drugs that have been misused by athletes.

Prednisone works partly as an immunosuppressant. Your immune system protects you from foreign bacteria and viruses. In some diseases, your immune system becomes overactive and attacks your body. These diseases are called “autoimmune diseases.” Some autoimmune diseases, including myasthenia gravis, are caused by antibodies. Prednisone suppresses the production of antibodies. This suppression can make it a little harder for you to fight infection, but it also reduces the overactivity of your immune system. When you start taking prednisone, there is a small chance that it may cause increased weakness for a short period of time. Most doctors try to prevent this by starting prednisone at a low dose and working up to a therapeutic level.

How are prednisone dosages determined? Schedules are determined by your body's response to prednisone. The severity of your myasthenia, control of your myasthenia symptoms, and the development of side effects are all taken into account when your doctor determines your prednisone dosage. You and your doctor will work together to try to reach the lowest possible dose to keep you strong enough. You may also discuss adding other immunosuppressants to your steroids, such as mycophenolate or azathioprine, to help lower your prednisone dosage.

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